"No him, no me. No MOST of us, comedy-wise," tweeted comic Patton Oswalt.
Winters had made television history in 1956, when RCA broadcast the first public demonstration of color videotape on "The Jonathan Winters Show."
The comedian quickly realized the possibilities, author David Hajdu wrote in The New York Times in 2006. He soon used video technology "to appear as two characters, bantering back and forth, seemingly in the studio at the same time. You could say he invented the video stunt."
Winters was born Nov. 11, 1925, in Dayton, Ohio. Growing up during the Depression as an only child whose parents divorced when he was 7, Winters spent a lot of time entertaining himself.
Winters, who himself battled alcoholism in his younger years, described his father as an alcoholic. But he found a comedic mentor in his mother, radio personality Alice Bahman.
"She was very fast. Whatever humor I've inherited I'd have to give credit to her," Winters told the Cincinnati Enquirer in 2000.
Winters joined the Marines at 17 and served two years in the South Pacific. He returned to study at the Dayton Art Institute, helping him develop keen observational skills. At one point, he won a talent contest (and the first prize of a watch) by doing impressions of movie stars.
After stints as a radio disc jockey and TV host in Ohio from 1950-53, he left for New York, where he found early work doing impressions of John Wayne, Cary Grant, Marx and James Cagney, among others.
One night after a show, an older man sweeping up told him he wasn't breaking any new ground by mimicking the rich or famous.
"He said, 'What's the matter with those characters in Ohio? I'll bet there are some far-out dudes that you grew up with back in Ohio,'" Winters told the Orange County Register in 1997.