"Les Miserables" was named best musical or comedy and won acting honors for Hugh Jackman and Anne Hathaway.
"Zero Dark Thirty" star Jessica Chastain won the Globe for dramatic actress as a CIA agent obsessively pursuing Bin Laden.
Other acting prizes went to Jennifer Lawrence as best musical or comedy actress for the oddball romance "Silver Linings Playbook" and Christoph Waltz as supporting actor for the slave-revenge tale "Django Unchained."
"Les Miserables," the musical based on Victor Hugo's classic novel, earned Jackman the Globe for musical or comedy actor as tragic hero Jean Valjean. Hathaway won supporting actress as a single mom forced into prostitution.
"Thank you for this lovely blunt object that I will forevermore use as a weapon against self-doubt," Hathaway said, cradling her trophy.
Jackman was a bit hoarse from the flu, but his Globe win seemed to be the right antidote.
"I was kicking myself for not getting the flu shot, but it appears that you don't need one. I feel great," Jackman said.
But when it comes to Hollywood's highest honors, "Les Miserables" has the same obstacle as "Argo," also failing to earn a best-director slot for filmmaker Tom Hooper at the Oscars.
Last Thursday's Oscar nominations held other shockers, including the omission of fellow Globe directing nominee Kathryn Bigelow for "Zero Dark Thirty."
Clinton upstaged Hollywood's elite with a surprise appearance to introduce Spielberg's "Lincoln," which was up for best drama. The film chronicles Abraham Lincoln's final months as he tries to end the war and find common ground in a divided Congress to pass the 13th Amendment abolishing slavery.
Lincoln's effort was "forged in a cauldron of both principle and compromise," Clinton said. "This brilliant film shows us how he did it and gives us hope that we can do it again."