Missouri's Marcus Murphy set a school single-season record with his fourth kick return for touchdown, a 98-yard kickoff return in the second quarter right after the weather delay.
But the Tigers (3-4, 0-4) have been outscored 126-55 in their first season in the SEC, and have been competitive to the finish in only last week's 19-15 loss at home to Vanderbilt.
The rest of the season, Pinkel vowed that injuries will be no excuse.
"I told our team we have had a lot of issues, a backup quarterback and all this other stuff," Pinkel said. "From this point on, I don't care. We're going to move on and try to finish the season the right way."
Backup quarterback Corbin Berkstresser, a redshirt freshman subbing for injured James Franklin, was 12 for 29 for 126 yards with two interceptions. Missouri has next weekend off and Franklin could return from a left knee strain at home against Kentucky Oct. 27.
Kendial Lawrence had 33 yards on seven carries but Missouri finished with just 3 yards on 28 carries including 53 yards in losses by Berkstresser, 42 of them on a sack-lost fumble at the end of the half.
Lacy had a career-best 177 yards on 18 carries and three touchdowns, including a 73-yarder on the game's second snap, for his second 100-yard game of the year. Yeldon had 144 yards on 18 carries and two TDs, also his second time in triple digits this season.
"The running backs, we haven't had a big run in a long time," Lacy said. "Our plan was to come in and run the ball, we didn't know how successful it was going to be. But as it turned out it was very successful."
Trent Richardson and Jalston Fowler each gained more than 100 yards for Alabama at Mississippi last October.