"The game is never won, just like it was never won last year when we were down at their place and came back and won," Vanderbilt coach James Franklin said. "They did the same thing to us. We got a taste of our own medicine."
Freeze came in with possibly the best recruiting class in Ole Miss history, and he put nine on the field in their first game. Treadwell started and caught a team-high nine passes for 82 yards, and freshman tight end Evan Engram had five catches for 61 yards.
Defensive end Robert Nkemdiche, the consensus No. 1 player coming out of high school, started and also ran for 11 yards on a fake punt on fourth-and-1 late in the first half.
But it was Scott, a senior, who provided the biggest play of the game. He took a handoff and beat a defensive lineman to the edge, then outraced the Commodores to the end zone. Andre Hal had one last chance to trip him up at the 20 but couldn't bring Scott down. Scott finished with 138 yards on 12 carries.
"I knew that it would be a good run play," Freeze said. "Obviously, I didn't know it would go all the way to the house. But I thought it would be a good run play."
Vanderbilt had set its defense for a pass.
"They blocked us in space and (Scott) is fast," Franklin said.
Wallace tied his career-high, completing 31 passes out of 47 for 283 yards, and he also ran 18 times for 48 yards on plays that helped set up Scott's TD run. Backup quarterback Barry Brunetti ran for two TDs, and Ole Miss used its spread, hurry-up offense to out-gain Vanderbilt 489-426.
Carta-Samuels threw for 300, and Matthews finished with 10 catches for 178 yards. Junior Kyle Woestmann had two of Vanderbilt's four sacks by halftime, but the Commodores didn't get to Wallace in the second half.