Ole Miss took advantage of the Commodores' early mistakes and led 10-0. Vanderbilt answered with 21 straight points.
Freeze even went for it on fourth-and-1 late in the first half, with Nkemdiche taking the snap as the up back. The consensus No. 1 recruit coming out of high school ran 11 yards for the first down. The Rebels ran out of time, and Andrew Ritter's 55-yard field goal attempt was short and right.
The finish overshadowed a gutsy performance by Matthews. He went into the locker room for intravenous fluids early in the third quarter, and he took a hard hit from Prewitt on a catch late in the game. But Matthews caught a 42-yard pass on fourth-and-18 to set up Scheu's TD, giving Vandy its last lead.
"I'll be honest with you, I put a lot into that tackle," Prewitt said. "For him to get back up and come in there, that shows a lot of leadership. He is a great player."