About 100 Livestrong staff members gathered in a conference room as Armstrong told them "I'm sorry." He choked up during a 20-minute talk, expressing regret for the long-running controversy tied to performance-enhancers had caused, but stopped short of admitting he used them.
Before he was done, several members were in tears when he urged them to continue the charity's mission, helping cancer patients and their families.
"Heartfelt and sincere," is how Livestrong spokeswoman Katherine McLane described his speech.
Armstrong later huddled with almost a dozen people before stepping into a room set up at a downtown Austin hotel for the interview with Winfrey. The group included close friends and lawyers. They exchanged handshakes and smiles, but declined comment and no further details about the interview were released because of confidentiality agreements signed by both camps.
Winfrey has promoted her interview, one of the biggest for OWN since she launched the network in 2011, as a "no-holds barred" session, and after the voluminous USADA report — which included testimony from 11 former teammates — she had plenty of material for questions. USADA chief executive Travis Tygart, a longtime critic of Armstrong's, called the drug regimen practiced while Armstrong led the U.S. Postal Service team "the most sophisticated, professionalized and successful doping program that sport has ever seen."
USADA did not respond to requests for comment about Armstrong's confession.
Hein Verbruggen, the former president of the International Cycling Union, said Tuesday he wasn't ready to speak about the confession.
"I haven't seen the interview. It's all guessing," Verbruggen told the AP. "After that, we have an independent commission which I am very confident will find out the truth of these things."
For years, Armstrong went after his critics ruthlessly during his reign as cycling champion. He scolded some in public and didn't hesitate to punish outspoken riders during the race itself. He waged legal battles against still others in court.