"I'm just going to do everything in my power, the right way, to stand up," Malzahn said.
The SEC's top three offenses last season — Texas A&M, Auburn and Missouri — run no-huddle attacks. Mississippi's 78.3 plays per game led the league but all three averaged at least 72.
Malzahn's offense has helped the Tigers play for the national championship twice, including a loss to Florida State in January.
He doesn't believe fast offenses lead to more injuries.
"I've been running a fast-paced offense since 1997, and I've never felt like on either side that it was a health and safety issue on offense or even on the other side," Malzahn said.
He declined to say how often he runs plays within 10 seconds, but said the rule would have a big impact.
"It's just a complete rule change," Malzahn said. "It changes the dynamics of traditional football in a lot more ways than anyone would think. Not just if you get behind by a couple touchdowns and it's late in the game, you couldn't properly come back. But the way you coach your quarterbacks. Because it wouldn't just be 10 seconds.
"You got a 5-yard penalty, so it would probably be more of the four or five seconds into that. And it would just change the dynamics of football."