But just as he did against Michigan State, Duke star Seth Curry got hot after halftime, making two 3s in the first three minutes. Mason Plumlee dunked to tie the game at 42.
That, however, was all Louisville needed.
Clawing for every rebound, diving on the floor for loose balls and cranking the intensity up even higher on their ferocious defense, the Cardinals were not going to lose. And everyone, Duke included, knew it.
Smith, the most outstanding player of the Midwest Region, made a layup. Peyton Siva had a nice jumper at the top of the key, and then followed with a layup. Just like that, the Cardinals were off on a 20-4 run that sealed the victory.
Siva had 16 points and Luke Hancock added 10 for the Cardinals, who will play Wichita State in the national semifinals next Saturday. The ninth-seeded Shockers (30-8) added to their streak of upsets with a 70-66 victory over Ohio State on Saturday night.
Plumlee finished with 17 points and 12 rebounds. Curry added 12, all in the second half.
The Blue Devils (30-6) needed Curry to come up big as he did against Michigan State if they were going to have any chance against the Blue Devils. But Curry didn't take a shot until almost nine minutes into the game, and missed each of his three shots in the first half.
This was only the second time the Blue Devils have reached the regional finals and failed to make it to the Final Four. The only other time? In 1998, when the Blue Devils lost to eventual national champion Kentucky.
The loss prevented Krzyzewski — for now — from tying John Wooden's record of 12 Final Four appearances.