That has opened Obama up to fierce criticism, both in the U.S. and abroad. Among those leading the criticism is Arizona's Republican Sen. John McCain, who says America's credibility has been damaged because Obama has not taken more forceful action to stop the violence.
The president pushed back at those assertions in the interview aired Friday, saying that while the U.S. remains "the one indispensable nation," that does not mean the country should get involved everywhere immediately.
"Well, you know, I am sympathetic to Sen. McCain's passion for helping people work through what is an extraordinarily difficult and heartbreaking situation, both in Syria and in Egypt," he said.
"Sometimes what we've seen is that folks will call for immediate action, jumping into stuff, that does not turn out well," he said. "We have to think through strategically what's going to be in our long-term national interests, even as we work cooperatively internationally to do everything we can to put pressure on those who would kill innocent civilians."
The U.S. has called on Syria to allow the U.N. team currently on the ground to investigate this most recent attack. However, the president was pessimistic about those prospects, saying, "We don't expect cooperation, given their past history."
More than 100,000 people have been killed in Syria during more than two years of clashes between forces loyal to Syrian President Bashar Assad and opposition fighters seeking to overthrow his regime. The U.S. has long called for Assad to go and has sent humanitarian aid to the rebels, but those steps have failed to push the Syrian leader from power.
After the earlier chemical weapons attacks, Obama did approve the shipments of small weapons and ammunition to the Syrian rebels, but there is little sign that the equipment has arrived.
Obama addressed the deepening crisis in Syria from central New York, where he is on a two-day bus tour promoting policies to make college more affordable.